CSF Indices After Repeated Spinal Taps in Horses Diagnosed with Equine Protozoal Myeloencephalitis

نویسندگان

  • Frank M. Andrews
  • Frederico Latimer
  • Steven Grubbs
چکیده

After prolonged treatment in horses for equine protozoal myeloencephalitis (EPM), cerebrospinal fluid antibodies to Sarcocystic neurona may persist. The albumin quotient did not change and the IgG index decreased in horses with EPM after repeated spinal taps 2–3 months apart. A decrease in IgG index, a measure of intrathecal antibody production, may indicate a favorable response to treatment for EPM. Authors’ address: Dept. of Large Animal Clinical Sciences, College of Veterinary Medicine, The University of Tennessee, P.O. Box 1071, Knoxville, TN 37901-1071. r 1997 AAEP.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Lymphocyte phenotype subsets in the cerebrospinal fluid of normal horses and horses with equine protozoal myeloencephalitis.

The percentages of T-lymphocytes, lymphocyte subsets CD4+ and CD8+ T-cells, and lymphocyte adhesion molecule CD11a/CD18 were determined in the peripheral blood and cerebrospinal fluid (CSF) of seven normal horses and four horses with equine protozoal myeloencephalitis (EPM) using flow cytometry. There was a greater percentage of CD5+ cells in the CSF (79.0%) than in peripheral blood (67.0%), al...

متن کامل

Equine Protozoal Myeloencephalitis– A Comparison of Western Blot Results for Serum and Cerebral Spinal Fluid With Postmortem Findings in Normal and Neurologic Horses

The western blot (WB) for S. neurona performed on serum and spinal fluid (CSF) is widely used for antemortem diagnosis of neurologic disease and for screening normal horses. Because CSF collection is difficult, the WB is often performed on the more readily available serum sample only. However, seroprevalence to S. neurona is high in normal horses and studies to evaluate the blood test have not ...

متن کامل

Inoculation of Sarcocystis neurona merozoites into the central nervous system of horses.

Equine protozoal myeloencephalitis (EPM) is a neurologic syndrome in horses from the Americas and is usually caused by infection with the apicomplexan parasite, Sarcocystis neurona. A horse model of EPM is needed to test the efficacy of chemotherapeutic agents and potential vaccines. Five horses that were negative for antibodies to S. neurona in their serum and cerebrospinal fluid (CSF) were in...

متن کامل

Clinical diagnosis of equine protozoal myeloencephalitis (EPM).

Equine protozoal myeloencephalitis (EPM) has been widely described in the veterinary literature. Even in appropriately treated horses it can be a progressive, debilitating neurological disease. Either of the known causative agents, Sarcocystis neurona (common) and Neospora hughesi (rare), can produce signs of focal or multifocal central nervous system disease. Although spinal ataxia and weaknes...

متن کامل

Cytokine gene signatures in neural tissue of horses with equine protozoal myeloencephalitis or equine herpes type 1 myeloencephalopathy.

This study was designed to determine the relative levels of gene transcription of selected pathogens and cytokines in the brain and spinal cord of 12 horses with equine protozoal myeloencephalitis (EPM), 11 with equine herpesvirus type 1 (EHV-1) myeloencephalopathy, and 12 healthy control horses by applying a real time pcr to the formalin-fixed and paraffin-embedded tissues. Total rna was extra...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 1997